Overview
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.7
USERS' SCORE
Good
Based on 15 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₁₂ (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
8
We examined the role of vitamin B status on mortality rates, focusing on cardiovascular disease. Using data from over 12,000 adults, we found that higher scores on the combined vitamin B status indicator (3cB) were linked to lower risks of dying from cardiovascular issues. Specifically, individuals with lower 3cB scores faced significantly higher risks of mortality. This suggests that maintaining adequate vitamin B levels could potentially play an important part in reducing cardiovascular disease-related deaths.
Read More
8
Vitamin B12 reduces cardiovascular risks
We explored the connection between vitamin B12, genetic factors, and cardiovascular health in a group of Chinese adults suffering from hypertension. By analyzing the genetic variations of individuals, we aimed to understand how these may influence levels of homocysteine, an amino acid that can impact heart health when present in high amounts.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Read More
7
We examined the link between folic acid and vitamin B12 levels and high blood pressure in children and adolescents. Using a nested case-control and cohort study design, we found that those with elevated blood pressure had lower levels of these vitamins compared to control groups. Notably, low folic acid levels were associated with higher blood pressure readings and an imbalance in lipid levels. Our findings highlight the importance of ensuring adequate intake of folic acid and vitamin B12 in childhood, either through diet or supplements, to help regulate blood pressure.
Read More
Most Useful Reviews
9
Eased symptoms effectively
9 people found this helpful
This product has alleviated my severe folic acid and B12 deficiency symptoms, such as numbness and muscle pain. Unlike injections, these easy-to-take pills have shown remarkable results. I feel energised, and the sweet taste makes it enjoyable. I highly recommend it for overall well-being.
Read More
8
Improves overall vitality
3 people found this helpful
I switched to methylcobalamin for easier absorption without straining my liver. Dissolving the lozenges quickly delivers the vitamin, enhancing my energy levels and reducing fatigue, which could also help mitigate risks associated with cardiovascular disease.
Read More
9
Essential for elderly
2 people found this helpful
This wonderful complex of B vitamins (B12, B6, B9) is crucial for managing chronic viral loads and homocysteine levels, which directly reduces the risk of cardiovascular disease, particularly in the elderly. I find its quality impressive.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.7
- All Researches
8
We examined the role of vitamin B status on mortality rates, focusing on cardiovascular disease. Using data from over 12,000 adults, we found that higher scores on the combined vitamin B status indicator (3cB) were linked to lower risks of dying from cardiovascular issues. Specifically, individuals with lower 3cB scores faced significantly higher risks of mortality. This suggests that maintaining adequate vitamin B levels could potentially play an important part in reducing cardiovascular disease-related deaths.
Read More
8
We investigated how exposure to metal mixtures during pregnancy influences blood pressure and hypertension later in life.
Using data from Project Viva, we followed 493 women over an average of 18 years.
Our findings revealed that higher levels of vitamin B12, along with essential metals like copper and manganese, were linked to lower blood pressure and reduced hypertension risk.
However, some metals showed mixed results, indicating a complex relationship.
Overall, optimizing nutrient levels during pregnancy may offer lasting benefits for women's cardiovascular health.
Using data from Project Viva, we followed 493 women over an average of 18 years.
Our findings revealed that higher levels of vitamin B12, along with essential metals like copper and manganese, were linked to lower blood pressure and reduced hypertension risk.
However, some metals showed mixed results, indicating a complex relationship.
Overall, optimizing nutrient levels during pregnancy may offer lasting benefits for women's cardiovascular health.
Read More
8
Vitamin B12 reduces cardiovascular risks
We explored the connection between vitamin B12, genetic factors, and cardiovascular health in a group of Chinese adults suffering from hypertension. By analyzing the genetic variations of individuals, we aimed to understand how these may influence levels of homocysteine, an amino acid that can impact heart health when present in high amounts.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Read More
7
We examined a unique case involving a 57-year-old man who experienced a myocardial infarction due to coronary artery spasm. His condition was associated with high serum homocysteine levels and low vitamin B12. Following treatment with vitamin B12 and calcium channel antagonists, his homocysteine levels normalized, and he reported no further chest pain or spasm.
This case suggests that managing homocysteine levels might be an effective strategy in preventing coronary artery spasm, highlighting vitamin B12's potential role in cardiovascular health.
This case suggests that managing homocysteine levels might be an effective strategy in preventing coronary artery spasm, highlighting vitamin B12's potential role in cardiovascular health.
Read More
7
We investigated how blood levels of B vitamins, particularly B6 and B12, influence blood pressure variability (BPV) in individuals with essential hypertension.
Our study included 100 patients with hypertension and 100 healthy controls. We discovered that both B vitamin levels were notably lower in the hypertensive group, while their BPV indices were significantly higher.
Interestingly, those with higher levels of B vitamins showed reduced BPV, suggesting that boosting these vitamins might help manage hypertension. However, while the trend is promising, it doesn't establish a definitive cause-and-effect relationship.
Our study included 100 patients with hypertension and 100 healthy controls. We discovered that both B vitamin levels were notably lower in the hypertensive group, while their BPV indices were significantly higher.
Interestingly, those with higher levels of B vitamins showed reduced BPV, suggesting that boosting these vitamins might help manage hypertension. However, while the trend is promising, it doesn't establish a definitive cause-and-effect relationship.
Read More
User Reviews
USERS' SCORE
Good
Based on 15 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Eased symptoms effectively
9 people found this helpful
This product has alleviated my severe folic acid and B12 deficiency symptoms, such as numbness and muscle pain. Unlike injections, these easy-to-take pills have shown remarkable results. I feel energised, and the sweet taste makes it enjoyable. I highly recommend it for overall well-being.
Read More
8
Improves overall vitality
3 people found this helpful
I switched to methylcobalamin for easier absorption without straining my liver. Dissolving the lozenges quickly delivers the vitamin, enhancing my energy levels and reducing fatigue, which could also help mitigate risks associated with cardiovascular disease.
Read More
9
Essential for elderly
2 people found this helpful
This wonderful complex of B vitamins (B12, B6, B9) is crucial for managing chronic viral loads and homocysteine levels, which directly reduces the risk of cardiovascular disease, particularly in the elderly. I find its quality impressive.
Read More
9
Prevents health issues
1 people found this helpful
This bioidentical methylcobalamin vitamin B12 is essential for maintaining brain and nerve health, with severe deficiencies leading to various health problems including those affecting cardiovascular disease. It has improved my sleep quality, enhancing overall life quality.
Read More
8.5
Improves cognitive function
1 people found this helpful
I often recommend Jarrow Formulas Methyl B12 to my clients due to its superior absorption and positive effects on the nervous system. Adequate B12 levels help combat fatigue, boost mood, and lower homocysteine, a risk factor in cardiovascular disease. The chewable tablets are a convenient choice.
Read More
Frequently Asked Questions
8.5
Improves cognitive function
1 people found this helpful
I often recommend Jarrow Formulas Methyl B12 to my clients due to its superior absorption and positive effects on the nervous system. Adequate B12 levels help combat fatigue, boost mood, and lower homocysteine, a risk factor in cardiovascular disease. The chewable tablets are a convenient choice.
7.5
Reduced homocysteine levels
72 people found this helpful
Vitamin B12 effectively reduces homocysteine, a vital factor in cardiovascular disease. We monitor this level yearly, and after taking B12 with pyridoxine and folic acid, my husband’s level dropped from 12 μmol/l to 8 μmol/l, which is a significant improvement. Given its importance after 50, we will continue to take it.
7.5
Effective preventative measure
1 people found this helpful
After developing Meniere's disease, I took B12 on recommendations and found relief. I now use it proactively, especially during episodes of stiff shoulders, as it works effectively and contributes to preventing potential cardiovascular disease complications.
8
We examined the role of vitamin B status on mortality rates, focusing on cardiovascular disease. Using data from over 12,000 adults, we found that higher scores on the combined vitamin B status indicator (3cB) were linked to lower risks of dying from cardiovascular issues. Specifically, individuals with lower 3cB scores faced significantly higher risks of mortality. This suggests that maintaining adequate vitamin B levels could potentially play an important part in reducing cardiovascular disease-related deaths.
7
We investigated how blood levels of B vitamins, particularly B6 and B12, influence blood pressure variability (BPV) in individuals with essential hypertension.
Our study included 100 patients with hypertension and 100 healthy controls. We discovered that both B vitamin levels were notably lower in the hypertensive group, while their BPV indices were significantly higher.
Interestingly, those with higher levels of B vitamins showed reduced BPV, suggesting that boosting these vitamins might help manage hypertension. However, while the trend is promising, it doesn't establish a definitive cause-and-effect relationship.
Our study included 100 patients with hypertension and 100 healthy controls. We discovered that both B vitamin levels were notably lower in the hypertensive group, while their BPV indices were significantly higher.
Interestingly, those with higher levels of B vitamins showed reduced BPV, suggesting that boosting these vitamins might help manage hypertension. However, while the trend is promising, it doesn't establish a definitive cause-and-effect relationship.
7
We examined a unique case involving a 57-year-old man who experienced a myocardial infarction due to coronary artery spasm. His condition was associated with high serum homocysteine levels and low vitamin B12. Following treatment with vitamin B12 and calcium channel antagonists, his homocysteine levels normalized, and he reported no further chest pain or spasm.
This case suggests that managing homocysteine levels might be an effective strategy in preventing coronary artery spasm, highlighting vitamin B12's potential role in cardiovascular health.
This case suggests that managing homocysteine levels might be an effective strategy in preventing coronary artery spasm, highlighting vitamin B12's potential role in cardiovascular health.
4
We investigated whether high levels of vitamin B-12 could influence stroke risk, especially considering gender differences. By analyzing data from the Korean Genome Epidemiology Study, we learned that while excessive vitamin B-12 on its own does not significantly raise stroke risk, it appears to increase stroke risk in men.
Our findings suggest that the interaction between high B-12 levels and sex plays an important role, highlighting a unique connection for males that isn't observed in females. It’s a nuanced look into vitamin B-12’s impact on cardiovascular health.
Our findings suggest that the interaction between high B-12 levels and sex plays an important role, highlighting a unique connection for males that isn't observed in females. It’s a nuanced look into vitamin B-12’s impact on cardiovascular health.
References
- Li Y, Wang H, Chen S, Wei Q, Liu Y, et al. The combined indicator of vitamin B status calculated using 3-parameters (3cB) is negatively associated with mortality among US adults: NHANES 1999 to 2004. Nutr Res. 2025;136:53. doi:10.1016/j.nutres.2025.02.008
- Ikeda A, Akama J, Ohki Y, Kunii H, Saitoh SI. Myocardial infarction with non-obstructive coronary artery caused by coronary artery spasm and an increase in serum homocysteine: a case report. Eur Heart J Case Rep. 2025;9:ytaf118. doi:10.1093/ehjcr/ytaf118
- Bian XY, Cui C, Zhang QY. Relationship between blood pressure variability and vitamin B level in essential hypertension. J Physiol Pharmacol. 2025;76. doi:10.26402/jpp.2025.1.02
- Zhang M, Aris IM, Cardenas A, Rifas-Shiman SL, Lin PD, et al. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study. Hypertension. 2025. doi:10.1161/HYPERTENSIONAHA.124.23980
- Chen X, Bishai D. Revisiting cost-effectiveness of folic acid supplementation in primary stroke prevention in China: considering vitamin B12 deficiency masking issue. BMC Public Health. 2024;24:3540. doi:10.1186/s12889-024-21005-7
- Chen B, Wang C, Li W. Genetic insights into the effect of trace elements on cardiovascular diseases: multi-omics Mendelian randomization combined with linkage disequilibrium score regression analysis. Front Immunol. 2024;15:1459465. doi:10.3389/fimmu.2024.1459465
- Liang X, Huang D, Bi Y, He Y, Mao T, et al. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study. J Hum Hypertens. 2024;38:844. doi:10.1038/s41371-024-00955-w
- Jung E, Kook HY, Ryu SJ, Ryu HH, Kim HG. The Association of Vitamin B-12 Plasma Concentration with Stroke Incidence According to Sex. J Nutr. 2024;154:3012. doi:10.1016/j.tjnut.2024.08.002
- Siddiqi SM, Liu L, Du Y, Song Y, Chen P, et al. Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension. J Nutr. 2024. doi:10.1016/j.tjnut.2024.09.003
